Baskin Steven I, Smith Lester, Hoey Leslie A, Levy Perri I, Goldfarb Allan H
Department of Pharmacology, Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, Pa. 19129, U.S.A.
Pain. 1981 Aug;11(1):1-8. doi: 10.1016/0304-3959(81)90134-2.
Aspirin can be an effective antipyretic, analgesic and anti-inflammatory agent, but unfortunately, its use in the elderly is often excessive [43]. In a survey by Gillies and Skyring, the overall prevalence of daily aspirin intake was greater in middle-age and older-age groups than for those of less than 40 years of age [16]. The elderly are susceptible to the advertising of non-prescription drugs and aspirin is frequently self-prescribed [8,31]. Age-related physiological changes modify the response to aspirin in the elderly. A higher incidence of drug reactions and interactions has been evidenced in this age group. The cases cited throughout this report substantiate the need for caution on the part of the geriatric patient and the physician in regard to aspirin therapy for the elderly.
阿司匹林可以是一种有效的解热、镇痛和抗炎药物，但不幸的是，它在老年人中的使用往往过量[43]。在吉利斯和斯凯林的一项调查中，中年和老年组每日服用阿司匹林的总体患病率高于40岁以下的人群[16]。老年人容易受到非处方药广告的影响，阿司匹林经常被自行用药[8,31]。与年龄相关的生理变化会改变老年人对阿司匹林的反应。在这个年龄组中，药物反应和相互作用的发生率更高。本报告中引用的病例证实了老年患者和医生在老年人阿司匹林治疗方面需要谨慎。
