Kreitmann O
Pathol Biol (Paris). 1981 Oct;29(8):503-11.
In vitro fertilization and embryo transfers have been considered recently as a potential therapeutic approach for infertile women having irreparable tubal failure. This procedure includes aspiration of the preovulatory follicle for oocyte recovery, in vitro fertilization using capacitated sperm, embryo development in culture, and ultimately embryo transfer into the uterine lumen. Despite the increasing number of attempts in humans by recently formed medical teams in several countries, the overall results are very limited and the reasons for so many failures are not clearly identified. In the present paper are reviewed the results obtained in the development of an experimental model among non human primates. It is likely that only the detailed analysis of each step of the procedure, using this model, will clarify some of the problems encountered, and allow for improvements of further attempts in humans.
体外受精和胚胎移植最近被视为一种针对输卵管功能无法修复的不孕女性的潜在治疗方法。该程序包括抽吸排卵前卵泡以回收卵母细胞,使用获能精子进行体外受精,在培养中进行胚胎发育,最终将胚胎移植到子宫腔内。尽管最近几个国家新组建的医疗团队在人类身上进行了越来越多的尝试,但总体结果非常有限,而且如此多失败的原因尚未明确。本文回顾了在非人类灵长类动物中建立实验模型所取得的结果。很可能只有使用该模型对程序的每个步骤进行详细分析,才能阐明所遇到的一些问题,并有助于改进在人类身上的进一步尝试。