Karam J, Gold L, Singer B S, Dawson M
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4669-73. doi: 10.1073/pnas.78.8.4669.
The bacteriophage T4 gene regA encodes a protein that diminishes the expression of many unlinked early T4 genes. Previous work demonstrated that regA-mediated repression occurs after transcription. We report here on the identification of the target site on one regA-sensitive mRNA, the message encoding the phage T4 rIIB protein. The target for regA-mediated action overlaps the translational initiation domain of the rIIB messenger. The regA protein may be a repressor that operates translationally on a significant and interesting set of early phage T4 mRNAs.
噬菌体T4基因regA编码一种可减少许多不连锁的早期T4基因表达的蛋白质。先前的研究表明，regA介导的阻遏作用发生在转录之后。我们在此报告对一个regA敏感mRNA上靶位点的鉴定，该mRNA编码噬菌体T4 rIIB蛋白。regA介导作用的靶标与rIIB信使的翻译起始结构域重叠。regA蛋白可能是一种阻遏物，对一组重要且有趣的早期噬菌体T4 mRNA进行翻译水平的调控。
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