Xiao Yu-Feng, Jie Meng-Meng, Li Bo-Sheng, Hu Chang-Jiang, Xie Rui, Tang Bo, Yang Shi-Ming
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
J Immunol Res. 2015;2015:761820. doi: 10.1155/2015/761820. Epub 2015 Oct 19.
Many new therapies are currently being used to treat cancer. Among these new methods, chemotherapy based on peptides has been of great interest due to the unique advantages of peptides, such as a low molecular weight, the ability to specifically target tumor cells, and low toxicity in normal tissues. In treating cancer, peptide-based chemotherapy can be mainly divided into three types, peptide-alone therapy, peptide vaccines, and peptide-conjugated nanomaterials. Peptide-alone therapy may specifically enhance the immune system's response to kill tumor cells. Peptide-based vaccines have been used in advanced cancers to improve patients' overall survival. Additionally, the combination of peptides with nanomaterials expands the therapeutic ability of peptides to treat cancer by enhancing drug delivery and sensitivity. In this review, we mainly focus on the new advances in the application of peptides in treating cancer in recent years, including diagnosis, treatment, and prognosis.
目前，许多新疗法正用于治疗癌症。在这些新方法中，基于肽的化疗因其独特优势而备受关注，比如分子量低、能够特异性靶向肿瘤细胞以及对正常组织毒性低。在癌症治疗中，基于肽的化疗主要可分为三种类型：单独肽疗法、肽疫苗和肽偶联纳米材料。单独肽疗法可能会特异性增强免疫系统对肿瘤细胞的杀伤反应。基于肽的疫苗已用于晚期癌症以提高患者的总生存率。此外，肽与纳米材料的结合通过增强药物递送和敏感性扩展了肽治疗癌症的能力。在本综述中，我们主要关注近年来肽在癌症治疗应用中的新进展，包括诊断、治疗和预后。
