通过体外试验检测十株泰国恶性疟原虫分离株对氯喹和乙胺嘧啶的耐药性。
Resistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests.
作者信息
Thaithong S, Beale G H
出版信息
Trans R Soc Trop Med Hyg. 1981;75(2):271-3. doi: 10.1016/0035-9203(81)90333-3.
In vitro drug resistance tests of ten isolates of Plasmodium falciparum from three different collection points in Central Thailand have been carried out, and the results compared with those of similar tests with a drug-sensitive West African isolate. Judged by concentration of drug tolerated, the Thai isolates appeared to be about 10 times as resistant to chloroquine, and usually about 10(5) times as resistant to pyrimethamine, as the African isolate. A little variation amongst the Thai isolates was detected.
对来自泰国中部三个不同采集点的10株恶性疟原虫分离株进行了体外耐药性测试，并将结果与对一种药物敏感的西非分离株的类似测试结果进行了比较。从耐受药物的浓度判断，泰国分离株对氯喹的耐药性似乎是非洲分离株的10倍左右，对乙胺嘧啶的耐药性通常是非洲分离株的10⁵倍左右。在泰国分离株中检测到了一些差异。
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