Julius U, Leonhardt W, Schulze J, Schollberg K, Hanefeld M, Haller H
Acta Diabetol Lat. 1981 Jul-Sep;18(3):217-23. doi: 10.1007/BF02047893.
In non-diabetic persons whose serum triglyceride (TG) concentrations ranged from normal to very high levels, endogenous TG turnover was measured using the radioglycerol method of Farquhar and coworkers. Insulin, FFA, and glucose concentrations were estimated during an oral glucose tolerance test. Stimulated insulin levels were correlated positively to TG concentrations and absolute TG turnover rates, and negatively to fractional TG catabolic rates. FFA concentrations had similar relationships, also in non-insulin-dependent diabetics. A more detailed analysis showed that elevated insulin and FFA levels - as an expression of peripheral insulin resistance - are typical finding in the kind of patients whose fractional TG catabolic rate is low [less than or equal to 0.210 (h-1)], irrespective of actual serum TG concentration. Our data do not suggest a stimulatory role of insulin for TG production.
在血清甘油三酯（TG）浓度从正常到非常高的非糖尿病患者中，采用法夸尔及其同事的放射性甘油法测量内源性TG周转率。在口服葡萄糖耐量试验期间估计胰岛素、游离脂肪酸（FFA）和葡萄糖浓度。刺激后的胰岛素水平与TG浓度和绝对TG周转率呈正相关，与TG分解代谢分数率呈负相关。FFA浓度也有类似关系，在非胰岛素依赖型糖尿病患者中也是如此。更详细的分析表明，胰岛素和FFA水平升高——作为外周胰岛素抵抗的一种表现——是TG分解代谢分数率低[小于或等于0.210（h-1）]的这类患者的典型表现，与实际血清TG浓度无关。我们的数据并不表明胰岛素对TG生成有刺激作用。
