Tchórzewski H, Afanasjew M, Pietrowicz D
Acta Physiol Pol. 1981 May-Jun;32(3):307-15.
The experiments were performed for localizing the inflammation-inducing factors in the subcellular fractions of human and guinea pig PMNL. The magnitude of the induced inflammation tested on rats and guinea-pigs represented combined effects of all proteins extracted from PMNL. The isolation of PMNL subcellular components did not elevate the potency of the inflammatory response. The inflammation was completely abolished with SH-dependent protease inhibitor. The inflammation induced by PMNL factors is a complex phenomenon which could not be attributed to special subcellular components.
进行这些实验是为了在人和豚鼠多形核白细胞（PMNL）的亚细胞组分中定位炎症诱导因子。在大鼠和豚鼠身上测试的诱导炎症的程度代表了从PMNL中提取的所有蛋白质的综合作用。PMNL亚细胞成分的分离并没有提高炎症反应的效力。使用依赖巯基的蛋白酶抑制剂可完全消除炎症。PMNL因子诱导的炎症是一种复杂的现象，不能归因于特殊的亚细胞成分。
