对乙酰氨基酚中毒的治疗。
Treatment of acetaminophen poisoning.
作者信息
Sellers E M, Freedman F
出版信息
Can Med Assoc J. 1981 Oct 15;125(8):827-9.
Acetaminophen is an analgesic that is frequently used in Canada, and the occurrence of overdoses with this drug seems to be increasing. The most serious complication of acetaminophen overdose is hepatic failure. Because of pathophysiologic effects of acetaminophen poisoning and the mechanisms of its toxic effects are now better understood, a rational approach to treatment is possible. Several precursors of glutathione, acetylcysteine in particular, are effective in preventing liver damage if administered within 10 hours of acetaminophen ingestion. Plasma acetaminophen levels are a helpful guide to therapy.
对乙酰氨基酚是一种在加拿大经常使用的镇痛药，这种药物过量服用的情况似乎在增加。对乙酰氨基酚过量服用最严重的并发症是肝衰竭。由于对乙酰氨基酚中毒的病理生理效应及其毒性作用机制现在已得到更好的理解，因此有可能采取合理的治疗方法。几种谷胱甘肽前体，特别是乙酰半胱氨酸，如果在摄入对乙酰氨基酚后10小时内给药，可有效预防肝损伤。血浆对乙酰氨基酚水平是治疗的有用指导。
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