Mampaso F, Gonzalo A, Teruel J, Losada M, Gallego N, Ortuno J, Bellas C
Clin Nephrol. 1981 Nov;16(5):230-4.
Kidney biopsies from fourteen patients with the nephrotic syndrome were studied by light, immunofluorescence and electron microscopy. Morphologically, all cases showed moderate diffuse mesangial cell proliferation. In all cases, immunofluorescent microscopy demonstrated diffuse and generalized deposits of IgM as the sole or predominant immunoglobulin. Electron microscopic examination showed electron dense deposits localized in the mesangium in seven cases. One nephrotic patient experienced spontaneous remission and eight others were steroid responsive. Only one of the five steroid resistant patients treated with chlorambucil showed clinical remission. Five steroid responsive patients relapsed. At present, four patients are healthy, having not relapsed for the past two years. Although deposits of IgM may be related to the renal pathology in cases of the nephrotic syndrome, immunofluorescence findings do not seem to be sufficiently consistent or characteristic to justify a possible subclassification of the idiopathic nephrotic syndrome.
对14例肾病综合征患者的肾活检组织进行了光镜、免疫荧光和电镜研究。形态学上，所有病例均显示中度弥漫性系膜细胞增生。所有病例中，免疫荧光显微镜检查均显示IgM弥漫性和全身性沉积，为唯一或主要的免疫球蛋白。电镜检查显示7例患者电子致密物沉积于系膜区。1例肾病患者自发缓解，另外8例对类固醇治疗有反应。在接受苯丁酸氮芥治疗的5例类固醇抵抗患者中，只有1例出现临床缓解。5例类固醇反应性患者复发。目前，4例患者健康，过去两年未复发。虽然IgM沉积可能与肾病综合征病例的肾脏病理有关，但免疫荧光结果似乎不够一致或具有特征性，不足以对特发性肾病综合征进行可能的亚分类。
