Vilches A R, Turner D R, Cameron J S, Ogg C S, Chantler C, Williams D G
Lab Invest. 1982 Jan;46(1):10-5.
During a 6-year period, 64 patients with a nephrotic syndrome, shown histologically to result from minimal change nephropathy, were studied for a mean of 4.5 years. Fifty of the patients showed no glomerular immunoglobulin on immunofluorescent or immunoperoxidase study, but 14 had mesangial deposits of IgM. The onset characteristics, response to treatment, and long-term course were similar in the two groups. We conclude that IgM deposition in the mesangium in patients with minimal change nephrotic syndrome is of no prognostic value, and our data do not suggest that this group of patients, although a histopathologic entity, represent a clinically distinct group.
在6年期间，对64例经组织学证实为微小病变肾病所致肾病综合征的患者进行了研究，平均随访4.5年。其中50例患者在免疫荧光或免疫过氧化物酶检查中未显示肾小球免疫球蛋白，但14例有系膜IgM沉积。两组患者的起病特征、治疗反应及长期病程相似。我们得出结论，微小病变肾病综合征患者系膜内IgM沉积无预后价值，且我们的数据并不表明这组患者尽管是一种组织病理学实体，但代表一个临床独特的群体。
