Agnew J E, Pavia D, Clarke S W
Eur J Respir Dis. 1981 Aug;62(4):239-55.
Several reports have claimed that inhaled radioaerosol particles show diminished lung penetration in subjects with impaired small airways function. Lung penetration may be estimated from the ratio of peripheral to central deposition, from the proportion of particles retained after 24 hours, from visual classification of gamma camera images or by computer analysis of the inhomogeneity of such images. Several approaches can characterise many young symptom-free smokers, or subjects with mild asthma, as "abnormal". Yet there is no convincing evidence from review of the literature and our own work that tests based on radioaerosol deposition are superior to other "small airways tests". Studies of particle deposition are, however, vital to the use of aerosols for investigating mucociliary clearance in the small airways.
几份报告称，在小气道功能受损的受试者中，吸入的放射性气溶胶颗粒在肺部的渗透能力会降低。肺渗透能力可通过外周沉积与中央沉积的比例、24小时后保留的颗粒比例、γ相机图像的视觉分类或通过对此类图像不均匀性的计算机分析来估算。有几种方法可以将许多无症状的年轻吸烟者或轻度哮喘患者判定为“异常”。然而，从文献综述和我们自己的研究来看，没有令人信服的证据表明基于放射性气溶胶沉积的测试优于其他“小气道测试”。不过，颗粒沉积研究对于利用气溶胶研究小气道中的黏液纤毛清除功能至关重要。
