Salo J, Silvennoinen E, Hulkko A, Ervasti E, Holopainen O
Ann Chir Gynaecol. 1981;70(4):187-90.
A total of 223 consecutive suspected appendicitis patients were treated preoperatively with parenteral tinidazole or physiological saline (control group). An infusion of 500 mg tinidazole was given to 110 patients over 30 minutes beginning about 30 minutes before the start of the operation, the control group comprised 111 patients. Postoperative infections were diagnosed in three patients in the group receiving tinidazole (3%) and in 17 patients in the control group (15%). The difference was statistically significant. There were no side-effects due to the drugs. Tinidazole appears to be well suited to the prophylaxis of post-appendicectomy infections.
总共223例连续的疑似阑尾炎患者在术前接受了静脉注射替硝唑或生理盐水治疗（对照组）。110例患者在手术开始前约30分钟开始的30分钟内输注500毫克替硝唑，对照组包括111例患者。接受替硝唑治疗的组中有3例患者（3%）被诊断为术后感染，对照组中有17例患者（15%）被诊断为术后感染。差异具有统计学意义。药物没有副作用。替硝唑似乎非常适合预防阑尾切除术后感染。
