Federspil P, Bamberg P
J Int Med Res. 1981;9(6):478-81. doi: 10.1177/030006058100900609.
In a randomized double-blind study fifty-four patients suffering from acute maxillary sinusitis were treated for 10 days with daily doses of sulphadiazine/trimethoprim (1 g) and sulphamethoxazole/trimethoprim (1.92 g), respectively. The efficacy was evaluated clinically at two follow-up visits. X-ray investigations were performed at admission and after the therapy. Of thirty-nine patients finally evaluated, thirty-seven showed a favourable result. After 6-8 days of therapy there was significant difference in cure rates in favour of sulphadiazine/trimethoprim (p less than 0.05) while the outcome as evaluated after treatment was similar for both drugs.
在一项随机双盲研究中，54例急性上颌窦炎患者分别接受了为期10天的磺胺嘧啶/甲氧苄啶（每日剂量1克）和磺胺甲恶唑/甲氧苄啶（每日剂量1.92克）治疗。在两次随访中对疗效进行了临床评估。在入院时和治疗后进行了X线检查。在最终评估的39例患者中，37例显示出良好的结果。治疗6 - 8天后，磺胺嘧啶/甲氧苄啶的治愈率有显著差异（p小于0.05），而两种药物治疗后的评估结果相似。
