Salmi H A
Chemotherapy. 1980;26(4):297-300. doi: 10.1159/000237920.
The combination of sulphadiazine 225 mg (SD) and trimethoprim 75 mg (TMP) was compared with the combination of sulphamethoxazole 400 mg (SM) and trimethoprim 80 mg (TMP) in the treatment of acute respiratory tract infection using a randomized double-blind clinical trial. The dose of both preparations was two tablets twice daily for 7-14 days. The patients were 200 conscripts hospitalized for an acute respiratory infection warranting antibacterial treatment. The most frequent diagnoses were pneumonia, bronchitis and tonsillitis. The combination SD/TMP was statistically significantly (p less than 0.001) superior to the combination of SM/TMP regarding overall efficacy of all indications. Especially pneumonia and bronchitis responded more favourably to SD/TMP than to SM/TMP. The duration of fever was also shorter (p less than 0.001) with SD/TMP than with SM/TMP. The occurrence of side effects was 2% in both treatment groups.
采用随机双盲临床试验，比较了磺胺嘧啶225毫克（SD）与甲氧苄啶75毫克（TMP）的组合和磺胺甲恶唑400毫克（SM）与甲氧苄啶80毫克（TMP）的组合在治疗急性呼吸道感染中的效果。两种制剂的剂量均为每日两次，每次两片，疗程7至14天。患者为200名因急性呼吸道感染需进行抗菌治疗而住院的应征入伍者。最常见的诊断为肺炎、支气管炎和扁桃体炎。就所有适应症的总体疗效而言，SD/TMP组合在统计学上显著优于SM/TMP组合（p小于0.001）。特别是肺炎和支气管炎对SD/TMP的反应比对SM/TMP更有利。SD/TMP组的发热持续时间也比SM/TMP组短（p小于0.001）。两个治疗组的副作用发生率均为2%。
