Federspil P, Koch J
Int J Clin Pharmacol Ther Toxicol. 1983 Oct;21(10):535-9.
Forty-two patients suffering from acute or recurrent ENT infections were given either 250 mg erythromycin 4 X daily or a new sulfamethopyrazine/trimethoprim combination (200 + 250 mg) once daily after a double loading dose on the 1st day, for 12 days on the average. Otitis media and externa, perichondritis, maxillary and frontal sinusitis were the most frequent clinical pictures. Assessment of efficacy was based on the course of objective and subjective clinical symptoms and, whenever possible, on bacteriologic findings. The new sulfa-trimethoprim combination showed activity similar to the reference drug, but it may have the advantage of a simpler dosage schedule.
42名患有急性或复发性耳鼻喉感染的患者，在第1天给予双倍负荷剂量后，要么每日4次服用250毫克红霉素，要么每日1次服用新的磺胺甲吡嗪/甲氧苄啶组合（200 + 250毫克），平均服用12天。中耳炎、外耳炎、软骨膜炎、上颌窦炎和额窦炎是最常见的临床表现。疗效评估基于客观和主观临床症状的病程，并尽可能基于细菌学检查结果。新的磺胺甲吡嗪/甲氧苄啶组合显示出与参比药物相似的活性，但它可能具有用药方案更简单的优势。
