Daneshmend T K, Homeida M M, Mountford R A, Brown P, Neumann C S
Gut. 1981 Dec;22(12):1045-7. doi: 10.1136/gut.22.12.1045.
Thirty-two patients with duodenal ulceration took trimipramine 50 mg or placebo. Fifteen patients on each treatment completed the study. Endoscopy at four weeks showed ulcer healing in seven (46%) patients on trimipramine, compared with only two (15%) on placebo (P less than 0.05). However, by eight weeks there were eight (53%) patients in both groups with healed ulcers. There were no significant differences between the two groups in ulcer symptoms. Drowsiness was reported by eight patients on trimipramine compared with only one on placebo. Trimipramine 50 mg appears to increase the rate of ulcer healing in the short term. Side-effects at the dose used may limit its long-term usefulness.
32例十二指肠溃疡患者服用50毫克三甲丙咪嗪或安慰剂。每种治疗方法各有15名患者完成了研究。四周时的内窥镜检查显示，服用三甲丙咪嗪的患者中有7例（46%）溃疡愈合，而服用安慰剂的患者中只有2例（15%）溃疡愈合（P小于0.05）。然而，到八周时，两组均有8例（53%）患者溃疡愈合。两组在溃疡症状方面无显著差异。服用三甲丙咪嗪的患者中有8例报告有嗜睡症状，而服用安慰剂的患者中只有1例有嗜睡症状。50毫克三甲丙咪嗪似乎在短期内可提高溃疡愈合率。所用剂量的副作用可能会限制其长期效用。
