Rüdiger H W, Dreyer M
Hum Genet. 1983;63(2):100-6. doi: 10.1007/BF00291526.
Novel laboratory techniques such as the determination of proinsulin, insulin, C-peptide and insulin receptors have allowed further subclassification of diabetes mellitus today as representing a symptom rather than a disease. Numerous pathogenetic mechanisms of diabetes have been identified, many of these being genetically determined and this may extend possibilities for genetic counselling. As a geneticist's view, the pathogenetic concept of diabetes presented here is mostly confined to genetic mechanisms, leaving aside other influences on the development of diabetes such as hormones, viruses, nutrition and drugs. Mendelian inherited diabetic disorders are related to different pathogenetic principles where possible, being speculative in some cases.
诸如测定胰岛素原、胰岛素、C肽和胰岛素受体等新型实验室技术，使得如今糖尿病能够进一步细分，它现在被视为一种症状而非一种疾病。已经确定了糖尿病的多种发病机制，其中许多是由基因决定的，这可能会增加遗传咨询的可能性。从遗传学家的角度来看，这里提出的糖尿病发病机制概念主要局限于遗传机制，而忽略了其他对糖尿病发展的影响因素，如激素、病毒、营养和药物。孟德尔遗传糖尿病紊乱尽可能与不同的发病机制相关，在某些情况下具有推测性。
