Stratton C W, Weinstein M P, Reller L B
J Infect Dis. 1982 Feb;145(2):160-8. doi: 10.1093/infdis/145.2.160.
Few data are available to show how serum dilution test results correlate with results of antimicrobial assays and determinations of minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs). Serum dilution tests were performed for 65 patients with bacteremia from serious infections. Assays for antimicrobial agent levels and determinations fo MICs and MBCs against the infecting organisms were performed simultaneously. Mueller-Hinton broth and Mueller-Hinton broth supplemented with Ca++, Mg++, and pooled human serum were compared as diluents for the serum either medium yielded positive correlations, better correlations were found between measured and expected serum bactericidal activities when both ther serum dilution test dilutions and the MIC and MBC determinations were done in the supplemented MHB-human serum solution.
鲜有数据表明血清稀释试验结果与抗菌测定以及最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测定结果之间的相关性。对65例因严重感染导致菌血症的患者进行了血清稀释试验。同时对感染病原体进行了抗菌剂水平测定以及MIC和MBC测定。比较了用Mueller-Hinton肉汤以及添加了Ca++、Mg++和混合人血清的Mueller-Hinton肉汤作为血清稀释剂的情况，两种培养基均产生了正相关，当血清稀释试验稀释以及MIC和MBC测定均在添加了人血清的改良Mueller-Hinton肉汤（MHB）溶液中进行时，测得的和预期的血清杀菌活性之间发现了更好的相关性。
