Huang T W
Ren Physiol. 1980;3(1-6):312-6. doi: 10.1159/000172776.
Differential response to 5 M guanidine, pH 7.0, shows at least two classes of glomerular basal laminas: epithelial and endothelial-mesangial. The former is the predominant element, folding into capillary tufts and loops but never completely encircle the entire circumference of glomerular capillaries. It remains as a single, continuous sheet within each glomerulus. The mesangial basal lamina partitions the vascular space into individual capillary lumen. The endothelial basal lamina, which extends from mesangium to encircle capillary lumens, is poorly developed, and undetectable in most capillaries. The organization of these two classes of basal laminas provides a structural framework for understanding glomerular permeability, especially the spatial relationship between capillary lumens and the mesangium. Interruption of the juxtaglomerular epithelial basal lamina, with sprouting of a new endothelial-mesangial bud, and formation of a new glomerular capillary tuft are noted in a group of patients with diabetic glomerulosclerosis and chronic renal failure. Wrinkling and resorption of the juxtamesangial epithelial basal lamina with formation of a new epithelial basal lamina are also observed. These findings indicate that the mesangium and the juxtamesangial epithelial basal lamina may be the active site of glomerular basal lamina resorption, turnover, and neoangiogenesis.
对pH值为7.0的5M胍的不同反应表明，肾小球基底膜至少有两类：上皮性和内皮-系膜性。前者是主要成分，折叠成毛细血管袢和环，但从未完全环绕肾小球毛细血管的整个圆周。它在每个肾小球内保持为单一的连续薄片。系膜基底膜将血管空间分隔成单个毛细血管腔。内皮基底膜从系膜延伸以环绕毛细血管腔，发育不良，在大多数毛细血管中无法检测到。这两类基底膜的组织为理解肾小球通透性提供了一个结构框架，特别是毛细血管腔与系膜之间的空间关系。在一组糖尿病肾小球硬化和慢性肾衰竭患者中，观察到近球上皮基底膜中断，伴有新的内皮-系膜芽的萌发和新的肾小球毛细血管袢的形成。还观察到近系膜上皮基底膜的褶皱和吸收，并形成新的上皮基底膜。这些发现表明，系膜和近系膜上皮基底膜可能是肾小球基底膜吸收、更新和新生血管形成的活跃部位。
