雌二醇刺激大鼠肾皮质中的乙醇脱氢酶活性。

Alcohol dehydrogenase activity in rat kidney cortex stimulated by oestradiol.

作者信息

Dembić Z, Sabolić I

出版信息

Biochim Biophys Acta. 1982 Feb 2;714(2):331-6. doi: 10.1016/0304-4165(82)90341-5.

Abstract

Sex differences in alcohol dehydrogenase activity, determined by the influence of oestrogen hormones, were found to exist in the rat kidney. Oestradiol, but neither testosterone nor progesterone, was shown to be a powerful stimulator of kidney alcohol dehydrogenase activity in rats, maximally 6- to 8-times over control values. The Michaelis-Menten constant for acetaldehyde of both non-stimulated and oestradiol-stimulated kidney alcohol dehydrogenases was found to be similar, 6.7 x 10(-5) M and 7.8 x 10(-5) M, respectively. Actinomycin D was shown to have an additive effect (superinduction) on the oestradiol-induced increase in kidney enzyme activity. The findings suggest the possibility of the higher contribution of kidneys in ethanol intake and ethanol hepatic disease.

摘要

研究发现，受雌激素影响，大鼠肾脏中乙醇脱氢酶活性存在性别差异。雌二醇被证明是大鼠肾脏乙醇脱氢酶活性的有力刺激物，而睾酮和孕酮则不是，其刺激后的活性最高比对照值高6至8倍。未受刺激和经雌二醇刺激的肾脏乙醇脱氢酶对乙醛的米氏常数相似，分别为6.7×10⁻⁵M和7.8×10⁻⁵M。放线菌素D对雌二醇诱导的肾脏酶活性增加具有累加效应（超诱导）。这些发现提示，肾脏在乙醇摄入和乙醇性肝病中可能发挥更大作用。