Wolff G, Langenstein H, Schwendener R, Lischer P
Intensive Care Med. 1982 Jan;8(1):39-48. doi: 10.1007/BF01686852.
In patients ventilated for acute respiratory failure PEEP was changed either by gradual increase and decrease (5 cm H2O/min) or in steps of 5 cm H2O. The effects on gas exchange, pulmonary mechanics and pulmonary and systemic circulation were studied. Total compliance did not change uniformly and cardiac index decreased so much due to PEEP that the increase in PaO2 could not prevent the decrease of arterial oxygen transport. No variable was found helpful to predict the "best PEEP" in a clinical situation.
在因急性呼吸衰竭而接受通气治疗的患者中，呼气末正压（PEEP）的改变方式为逐渐增加和降低（5厘米水柱/分钟）或每次增加5厘米水柱。研究了其对气体交换、肺力学以及肺循环和体循环的影响。总顺应性并非均匀变化，且由于PEEP导致心脏指数大幅下降，以至于动脉血氧分压（PaO2）的升高无法阻止动脉氧运输的降低。未发现有任何变量有助于在临床情况下预测“最佳PEEP”。
