对4-氯甲基联苯及其2种结构类似物进行细菌诱变性试验。

Bacterial mutagenicity tests on 4-chloromethylbiphenyl and 2 structural analogues.

作者信息

Kirkland D J, Smith K L, Parmar V

出版信息

Mutat Res. 1982 Jan-Feb;100(1-4):21-5. doi: 10.1016/0165-1218(82)90014-3.

DOI:10.1016/0165-1218(82)90014-3

Abstract

4CMB, 4HMB and BC were tested in 5 strains of S. typhimurium and 2 strains of E. Coli without S9. 4HMB was negative in all strains. 4CMB was a strong positive mutagen in TA1535, TA1538, TA98, TA100 and WP2uvrA-(pKM101), and BC was a weak mutagen in TA100 and WP2uvrA-(pKM101). Positivity was determined as a dose response over 3 or more points, in repeat experiments, giving a significant correlation coefficient.

摘要

在无S9的情况下，对5株鼠伤寒沙门氏菌和2株大肠杆菌进行了4 - 氯- 3,5 - 二甲基苯胺（4CMB）、4 - 羟基- 3,5 - 二甲基苯胺（4HMB）和苄基咔唑（BC）测试。4HMB在所有菌株中均呈阴性。4CMB在TA1535、TA1538、TA98、TA100和WP2uvrA -（pKM101）中是强阳性诱变剂，而BC在TA100和WP2uvrA -（pKM101）中是弱诱变剂。在重复实验中，阳性判定为超过3个或更多点的剂量反应，具有显著的相关系数。

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