英国环境诱变剂学会试验：使用大肠杆菌WP2uvrA(pKM101)、鼠伤寒沙门氏菌TA98和TA100对4-氯甲基联苯、4-羟甲基联苯和苄基氯进行细菌突变试验。
UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100.
作者信息
Venitt S, Crofton-Sleigh C, Bosworth D A
出版信息
Mutat Res. 1982 Jan-Feb;100(1-4):39-43. doi: 10.1016/0165-1218(82)90018-0.
4CMB, 4HMB and BC were assayed in plate tests, using E. coli WP2urvA(pKM101), and S. typhimurium TA98 and TA100, in the presence or absence of microsomal activation. 4CMB was also assayed in fluctuation tests using E. coli WP2uvrA(pKM101). 4HMB was uniformly negative, and 4CMB was mutagenic to all 3 strains. BC was negative in TA98 and positive in TA100 and WP2uvrA(pKM101). The presence of absence of S9 made no substantial difference to the mutagenicity of 4CMB or BC.
在平板试验中，使用大肠杆菌WP2urvA(pKM101)、鼠伤寒沙门氏菌TA98和TA100，在有或没有微粒体激活的情况下，对4CMB、4HMB和BC进行了检测。还使用大肠杆菌WP2uvrA(pKM101)在波动试验中对4CMB进行了检测。4HMB均为阴性，4CMB对所有3种菌株均具有致突变性。BC在TA98中为阴性，在TA100和WP2uvrA(pKM101)中为阳性。S9的存在与否对4CMB或BC的致突变性没有实质性影响。
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