Mabuchi H, Tatami R, Haba T, Ueda K, Ueda R, Ito S, Karnetani T, Koizurni J, Miyamoto S, Ohta M, Takeda R, Takegoshi T, Takeshita H
Metabolism. 1978 Nov;27(11):1672-9. doi: 10.1016/0026-0495(78)90289-5.
Achilles tendon thickness (ATT) of 112 patients with familial hypercholesterolemia (FH) with and without ischemic heart disease (IHD) was measured radiographically and was compared with that of normal subjects. The mean and SD of serum cholesterol in the heterozygotes (107 cases), the homozygotes (5 cases) and the normal subjects (36 cases) were 347 +/- 63, 589 +/- 69 and 187 +/- 30 mg/dl, respectively. The mean and SEM of ATT in the heterozygotes, the homozygotes and the normal subjects were 12.5 +/- 0.4 mm, 18.6 +/- 6.6 mm, and 6.3 +/- 0.2 mm, respectively. Cutaneous xanthomas were observed in 34 out of 112 patients (30.4%). Increased ATT was observed in 95 (84.8%). IHD was diagnosed in 39 (34.8%). The ATT of FH with IHD was significantly thicker than that of FH without IHD (P less than 0.05) and that of normal subjects (p less than 0.001). Thus, the increased ATT evaluated by x-ray was the earliest clinical sign of FH and the measurement of ATT seems to be a useful adjunctive procedure for detecting familial hypercholesterolemic patients and predicting IHD in them.
对112例患有或未患有缺血性心脏病（IHD）的家族性高胆固醇血症（FH）患者的跟腱厚度（ATT）进行了影像学测量，并与正常受试者的跟腱厚度进行比较。杂合子（107例）、纯合子（5例）和正常受试者（36例）的血清胆固醇均值和标准差分别为347±63、589±69和187±30mg/dl。杂合子、纯合子和正常受试者的ATT均值和标准误分别为12.5±0.4mm、18.6±6.6mm和6.3±0.2mm。112例患者中有34例（30.4%）观察到皮肤黄色瘤。95例（84.8%）观察到ATT增加。39例（34.8%）被诊断为IHD。患有IHD的FH患者的ATT明显厚于未患有IHD的FH患者（P<0.05）和正常受试者（P<0.001）。因此，通过X线评估的ATT增加是FH最早的临床体征，测量ATT似乎是检测家族性高胆固醇血症患者并预测其IHD的有用辅助检查。
