Fagerholm P P
Acta Ophthalmol (Copenh). 1980 Dec;58(6):963-70. doi: 10.1111/j.1755-3768.1980.tb08323.x.
Rats lens epithelial cells were allowed to regenerate on the lens capsule in tissue cultured. The major part of the lens fibers had been removed. After a month spherical bodies appeared, similar in appearance to Elschnig's pearls. Electron microscopical examination revealed that these spheres consisted of large extracellular vacuoles, and phase contrast examination revealed a continuous change in appearance of these spheres. The mechanism behind the tendency to form extracellular vacuoles probably include an increased extrusion of sodium and water from osmotically stressed lens cells.
