Stoff J S
Am J Med. 1982 Mar;72(3):489-95. doi: 10.1016/0002-9343(82)90520-4.
The clinical importance of an understanding of phosphate metabolism is derived from the crucial role of this anion in the regulation of many cellular functions. In recent years, a greater appreciation of disorders of phosphate metabolism has been recognized because of more frequent monitoring of serum phosphate concentration as well as the increased utilization of therapeutic interventions that profoundly affect overall phosphate balance. The present review focuses on the factors tha regulate phosphate homeostasis, explores the pathophysiology and manifestations of the phosphate depletion syndrome and provides a framework for the diagnosis and rational treatment of patients with abnormalities in phosphate metabolism.
了解磷酸盐代谢的临床重要性源于这种阴离子在调节许多细胞功能中所起的关键作用。近年来，由于对血清磷酸盐浓度的监测更加频繁，以及对整体磷酸盐平衡有深远影响的治疗干预措施的使用增加，人们对磷酸盐代谢紊乱有了更深入的认识。本综述重点关注调节磷酸盐稳态的因素，探讨磷酸盐耗竭综合征的病理生理学和表现，并为诊断和合理治疗磷酸盐代谢异常的患者提供一个框架。
