Antisperm antibodies and human infertility.

In a trial to evaluate the role of antisperm antibodies in human infertility, 120 couples (30 normal controls and 90 suffering from various types of infertility) were examined for the presence of agglutinating antibodies (by the Kibrick and Franklin-Dukes methods) and immobilizing antibodies in the serum, cervical mucus, and seminal plasma. In the male partners the highest and most significant incidence was found in the serum and seminal plasma of the group with poor sperm motility. In the female partners the highest and most significant incidence was found in the serum and cervical mucus of the group with unexplained infertility. It was concluded that it is greatly advisable to test for antisperm antibodies in selected groups of infertile couples.