Havdrup T, Henricson A, Telhag H
Acta Orthop Scand. 1982 Feb;53(1):119-24. doi: 10.3109/17453678208992188.
When diluted papain is injected intra-articularly into the knee joints of adult rabbits, slowing progressing, degenerative changes develop in the articular cartilage. After intravenous injection of crude papain no significant degenerative changes are found. With the aid of radioactive thymidine, it is possible to demonstrate that the chondrocytes recover their ability to divide before any degenerative changes can be found. At the same time the matrix loses its staining properties with Safranin-O and toluidine blue.
当将稀释的木瓜蛋白酶关节内注射到成年兔的膝关节时，关节软骨会出现进展缓慢的退行性变化。静脉注射粗制木瓜蛋白酶后，未发现明显的退行性变化。借助放射性胸苷，可以证明软骨细胞在发现任何退行性变化之前就恢复了分裂能力。与此同时，基质失去了与番红O和甲苯胺蓝的染色特性。
