Mogg G A, George R H, Youngs D, Johnson M, Thompson H, Burdon D W, Keighley M R
Br J Surg. 1982 Mar;69(3):137-9. doi: 10.1002/bjs.1800690306.
Thirty-eight patients with severe antibiotic-associated postoperative diarrhoea were entered into a randomized controlled trial to compare colestipol (an ion exchange resin) in 17 patients with placebo (sherbet) in 21 patients. Clostridium difficile or its toxin was present before treatment in 12 of the colestipol group, compared with only 5 in the placebo group. Because of the low incidence of Cl. difficile or its toxin, the placebo group data from 22 patients receiving placebo in a previous trial (9 of whom had Cl. difficile or toxin) were included for comparison. Neither colestipol nor placebo had any influence on the faecal excretion of Cl. difficile or its toxin. Colestipol was clinically no better than placebo. In view of the persistent faecal excretion of Cl. difficile toxin, ion exchange resins cannot be recommended for the treatment of antibiotic-associated colitis.
38例患有严重抗生素相关性术后腹泻的患者进入一项随机对照试验，比较17例服用考来烯胺（一种离子交换树脂）的患者与21例服用安慰剂（果子露）的患者。考来烯胺组12例患者在治疗前存在艰难梭菌或其毒素，而安慰剂组仅有5例。由于艰难梭菌或其毒素的发生率较低，纳入了先前一项试验中22例接受安慰剂治疗患者（其中9例有艰难梭菌或毒素）的安慰剂组数据进行比较。考来烯胺和安慰剂对艰难梭菌或其毒素的粪便排泄均无任何影响。考来烯胺在临床上并不比安慰剂更好。鉴于艰难梭菌毒素持续从粪便中排出，离子交换树脂不推荐用于治疗抗生素相关性结肠炎。
