Bland R C
Can J Psychiatry. 1982 Feb;27(1):52-62. doi: 10.1177/070674378202700112.
Current concepts of schizophrenia and recent changes in diagnostic practice, multidimensional outcome assessment, and predictive methodology are reviewed. The highly successful results of earlier studies are not borne out in recent work which indicates that only about 8-40% of the outcome variance can be predicted using multivariate analysis of symptoms or groups of symptoms. Other influences during the illness which may significantly modify the outcome include the economic situation, life events, social class, the family, extrinsic handicaps, migration and culture. These factors have been inadequately considered in prognosis research, and are probably not considered sufficiently in therapy.
本文回顾了精神分裂症的当前概念以及诊断实践、多维度结果评估和预测方法的近期变化。早期研究取得的非常成功的结果在近期工作中并未得到证实，近期研究表明，使用症状或症状组的多变量分析只能预测约8%-40%的结果差异。疾病期间其他可能显著改变结果的影响因素包括经济状况、生活事件、社会阶层、家庭、外在障碍、移民和文化。这些因素在预后研究中未得到充分考虑，在治疗中可能也未得到足够重视。
