Heikinheimo M, Unnérus H A, Ranta T, Jalanko H, Seppälä M
Obstet Gynecol. 1978 Sep;52(3):276-8.
Plasma concentrations of pregnancy specific beta-1-glycoprotein (PSBG) were measured by specific radioimmunoassay in 211 samples from 123 normal women during the third trimester of pregnancy and in 166 samples from 68 patients with cholestasis of pregnancy. At 37--38 weeks of gestation patients with cholestasis had significantly lower PSBG levels than the normal pregnant women (P less than 0.005), whereas the levels in patients in the cholestasis had not been significantly different from those for normal pregnant women before 37 weeks. At 37--38 weeks of gestation patients with cholestasis showed a slight correlation between placnetal weight and plasma PSBS levels (r = 0.362; P less than 0.05), whereas this was not found in patients with normal pregnancy. No correlation was found between infant weight or length at birth and the PSBG concentrations in either group, and no difference was noted in PSBG concentrations between cases with and without fetal distress.
采用特异性放射免疫分析法，对123名正常孕妇妊娠晚期的211份样本以及68例妊娠胆汁淤积症患者的166份样本，测定了妊娠特异性β1 -糖蛋白（PSBG）的血浆浓度。在妊娠37 - 38周时，胆汁淤积症患者的PSBG水平显著低于正常孕妇（P < 0.005），而在37周前，胆汁淤积症患者的PSBG水平与正常孕妇相比无显著差异。在妊娠37 - 38周时，胆汁淤积症患者的胎盘重量与血浆PSBS水平之间存在轻微相关性（r = 0.362；P < 0.05），而正常妊娠患者未发现此相关性。两组中，出生时婴儿体重或身长与PSBG浓度之间均未发现相关性，有胎儿窘迫和无胎儿窘迫的病例之间PSBG浓度也无差异。
