Heikinheimo M, Paasivuo R, Wahlström T
Br J Cancer. 1981 May;43(5):654-8. doi: 10.1038/bjc.1981.96.
The synthesis of pregnancy-specific beta 1-glycoprotein (SP1) was studied in normal brain-derived and malignant glial-cell cultures. The normal brain-derived and glioma cells were found to contain SP1 when studied by radioimmunoassay and by the triple-bridge immunoperoxidase technique. The active synthesis of SP1 by these brain-derived cells was confirmed by metabolic labelling and subsequent immune precipitation of the culture medium. The SP1-like material produced by the brain-derived cells had the same molecular weight as purified placental SP1.
在正常脑源和恶性胶质细胞培养物中研究了妊娠特异性β1-糖蛋白（SP1）的合成。通过放射免疫测定法和双桥免疫过氧化物酶技术研究发现，正常脑源细胞和胶质瘤细胞中含有SP1。通过代谢标记和随后对培养基进行免疫沉淀，证实了这些脑源细胞可活跃合成SP1。脑源细胞产生的SP1样物质与纯化的胎盘SP1具有相同的分子量。
