Calvanico N J, Du Pont B L, Huang C J, Patterson R, Fink J N, Kurup V P
Clin Exp Immunol. 1981 Sep;45(3):662-71.
An antigen has been purified from the mycelial cell sap of Aspergillus fumigatus (strain 507). The same component appears to be present in the extracellular phase (culture filtrate) in a partially degraded form. The cell sap protein has a structure composed of four polypeptides of 45,000 daltons linked through disulphide bonds. The isoelectric point (5.2-5.6) and carbohydrate content (12.5% neutral hexose) indicate that this protein is an acidic glycoprotein. It shows reactions with 75% of sera from patients with aspergilloma and allergic bronchopulmonary aspergillosis and is not reactive with sera from normal individuals of patients with other fungal diseases. It also appears to be a component of other A. fumigatus strains.
一种抗原已从烟曲霉（菌株507）的菌丝体胞液中纯化出来。相同的成分似乎以部分降解的形式存在于细胞外阶段（培养滤液）中。胞液蛋白具有由通过二硫键连接的45,000道尔顿的四种多肽组成的结构。等电点（5.2 - 5.6）和碳水化合物含量（12.5%中性己糖）表明该蛋白是一种酸性糖蛋白。它与75%的曲菌球患者和过敏性支气管肺曲霉菌病患者的血清发生反应，而与正常个体或其他真菌疾病患者的血清无反应。它似乎也是其他烟曲霉菌株的一种成分。
