Kingston D
Clin Exp Immunol. 1981 Oct;46(1):225-8.
Recognition of the protein A-like activity of some strains of group A streptococci has thrown doubt on much previous work suggesting antigenic cross-reactions between these streptococci and mammalian tissues. The strains used in our previous studies have now been examined by the mixed reverse passive antiglobulin reaction (MRPAH) for the 'non-specific' absorption of purified Fc portion of human IgG. They were found to have only traces of activity. The strain of Staphylococcus aureus used to control 'non-specific' absorption by bacterial cell walls was strongly positive. Protein A-like material as detected in this way was not therefore responsible for our earlier results.
对某些A组链球菌菌株的类蛋白A活性的认识，使人们对之前许多表明这些链球菌与哺乳动物组织之间存在抗原交叉反应的研究产生了怀疑。我们之前研究中使用的菌株，现在已通过混合反向被动抗球蛋白反应（MRPAH）检测其对人IgG纯化Fc段的“非特异性”吸收情况。结果发现它们仅有微量活性。用于对照细菌细胞壁“非特异性”吸收的金黄色葡萄球菌菌株呈强阳性。因此，以这种方式检测到的类蛋白A物质并非我们早期结果的原因。
