Petermann W, Mulch G
Fortschr Med. 1982 Mar 11;100(10):431-5.
During the last few years betahistine-dihydrochloride has been used extensively in the conservative treatment of M. Ménière. The question has arisen as to whether betahistine-dihydrochloride is more effective than diuretics. The effect of betahistine-dihydrochloride was compared to that of hydrochlorothiazide on 32 M. Ménière-patients. The patients were initially kept under observation for 3 months without medication apart from symptomatic anti-vertigo agents. The patients were then assigned to 2 groups each of 16 subjects and received either 3 X 8 mg betahistine-dihydrochloride or 3 X 25 mg hydrochlorothiazide for 6 months under double-blind conditions. Before and during treatment subjective symptoms such as vertigo, attacks of dizziness, tinnitus, sensation of blockage in the ear and general well-being were assessed at 4-weekly intervals. Apart from this the objective symptoms as measured by pure tone audiograms, Frenzel-test and electronystagmography were recorded. At the moment betahistine-dihydrochloride seems to be the drug of choice for Ménière-patients with a fluctuating auditory threshold. During the 6 months treatment period an impressive reduction in the frequency, severity and duration of the attacks of vertigo as well as an improvement in the general condition was found in all patients. In contrast the diuretic hydrochlorothiazide seemed to show a distinct therapeutic effect on vertigo and general well-being principally during the first few months of treatment in patients with a constant auditory threshold.
在过去几年中，倍他司汀二盐酸盐已广泛用于梅尼埃病的保守治疗。倍他司汀二盐酸盐是否比利尿剂更有效这一问题已经出现。将32例梅尼埃病患者的倍他司汀二盐酸盐的效果与氢氯噻嗪的效果进行了比较。患者最初在无药物治疗的情况下观察3个月，仅使用对症抗眩晕药物。然后将患者分为两组，每组16名受试者，在双盲条件下接受3×8mg倍他司汀二盐酸盐或3×25mg氢氯噻嗪治疗6个月。在治疗前和治疗期间，每4周评估一次主观症状，如眩晕、头晕发作、耳鸣、耳部堵塞感和总体健康状况。除此之外，还记录了通过纯音听力图、Frenzel试验和眼震电图测量的客观症状。目前，倍他司汀二盐酸盐似乎是听觉阈值波动的梅尼埃病患者的首选药物。在6个月的治疗期内，所有患者的眩晕发作频率、严重程度和持续时间均显著降低，总体状况也有所改善。相比之下，利尿剂氢氯噻嗪似乎主要在治疗的最初几个月对听觉阈值恒定的患者的眩晕和总体健康状况显示出明显的治疗效果。
