痢疾志贺氏菌1型（志贺毒素）及类志贺毒素的免疫化学活性和细胞毒性活性
Immunochemical and cytotoxic activities of Shigella dysenteriae 1 (shiga) and shiga-like toxins.
作者信息
O'Brien A D, Laveck G D
出版信息
Infect Immun. 1982 Mar;35(3):1151-4. doi: 10.1128/iai.35.3.1151-1154.1982.
Abstract
Toxins in culture supernatants and bacterial lysates of S. dysenteriae 1 and S. flexneri were quantitated by a cytotoxicity assay and a newly developed radioimmunoassay. Cytotoxin titers paralleled toxin antigen levels. Thus, variations in cytotoxicity among shigellae probably reflect differences in toxin yield rather than specific activity (cytotoxicity per microgram of toxin antigen).
摘要
通过细胞毒性测定和新开发的放射免疫测定法对痢疾志贺氏菌1型和福氏志贺氏菌培养上清液及细菌裂解物中的毒素进行定量。细胞毒素滴度与毒素抗原水平平行。因此，志贺氏菌之间细胞毒性的差异可能反映了毒素产量的不同，而非比活性（每微克毒素抗原的细胞毒性）的差异。
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