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模拟体内条件下氨苄西林对大肠杆菌的抗菌动力学

Antibacterial kinetics of ampicillin against Escherichia coli under simulated in vivo conditions.

作者信息

Fuglesang J E, Bergan T

出版信息

Infection. 1982 Jan;10(1):31-4. doi: 10.1007/BF01640835.

DOI:10.1007/BF01640835
PMID:7040252
Abstract

We studied the response of Escherichia coli to ampicillin concentrations which decreased logarithmically at elimination half-life values (t1/2a) ranging from one to four hours. The rate of bacterial killing depended on the initial antibiotic concentration (co), but was not significantly affected by t1/2a. Irrespective of co and t1/2a, the bactericidal effect terminated after about three hours of exposure to the drug.

摘要

我们研究了大肠杆菌对氨苄青霉素浓度的反应，该浓度在消除半衰期值（t1/2a）从1小时到4小时范围内呈对数下降。细菌杀灭速率取决于初始抗生素浓度（co），但不受t1/2a的显著影响。无论co和t1/2a如何，在接触该药物约三小时后杀菌作用终止。

相似文献

1
Antibacterial kinetics of ampicillin against Escherichia coli under simulated in vivo conditions.模拟体内条件下氨苄西林对大肠杆菌的抗菌动力学
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2
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3
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Bacterial kill rates of amoxycillin and ampicillin at exponentially diminishing concentrations simulating in vivo conditions.在模拟体内条件下，阿莫西林和氨苄西林在指数递减浓度时的细菌杀灭率。
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引用本文的文献

1
Antibacterial activity and kill kinetics of amoxicillin-clavulanic acid combinations against Escherichia coli and Klebsiella aerogenes.
Infection. 1983 Nov-Dec;11(6):329-35. doi: 10.1007/BF01641359.
2
Antibacterial activity and kill kinetics of ampicillin/sulbactam (CP-45899) combinations against Escherichia coli and Klebsiella aerogenes.氨苄西林/舒巴坦（CP-45899）组合对大肠杆菌和产气克雷伯菌的抗菌活性及杀菌动力学
Infection. 1984 Jan-Feb;12(1):46-50. doi: 10.1007/BF01641025.
3
Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter.美西林/氨苄西林联合制剂对肠杆菌科细菌、假单胞菌和不动杆菌的抑制活性及杀菌动力学

本文引用的文献

1
The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms.青霉素在体外的杀菌作用速率与其浓度的关系，以及在高浓度时对某些生物体其活性反常降低的情况。
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An in vitro model for monitoring bacterial responses to antibiotic agents under simulated in vivo conditions.一种用于在模拟体内条件下监测细菌对抗生素药物反应的体外模型。
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Infection. 1981;9(6):290-5. doi: 10.1007/BF01640994.
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Kinetics and mechanisms of drug action on microorganisms. XVII. Bactericidal effects of penicillin, kanamycin, and rifampin with and without organism pretreatment with bacteriostatic chloramphenicol, tetracycline, and novobiocin.药物对微生物作用的动力学与机制。十七、青霉素、卡那霉素和利福平在有或没有用抑菌性氯霉素、四环素和新生霉素对微生物进行预处理情况下的杀菌作用。
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Lancet. 1972 Sep 2;2(7775):465-6. doi: 10.1016/s0140-6736(72)91858-2.
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Persistent effect of antibiotics on Staphylococcus aureus after exposure for limited periods of time.抗生素在短时间暴露后对金黄色葡萄球菌的持续影响。
J Infect Dis. 1977 Feb;135(2):217-23. doi: 10.1093/infdis/135.2.217.
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Bacteriological study on effects of beta-lactam group antibiotics in high concentrations.高浓度β-内酰胺类抗生素作用的细菌学研究
Antimicrob Agents Chemother. 1976 Jun;9(6):1033-42. doi: 10.1128/AAC.9.6.1033.
10
Bactericidal activity of cefadroxil, cephalexin, and cephradine in an in vitro pharmacokinetic model.头孢羟氨苄、头孢氨苄和头孢拉定在体外药代动力学模型中的杀菌活性。
J Antibiot (Tokyo). 1979 Jul;32(7):718-26. doi: 10.7164/antibiotics.32.718.