Cantor K P
Int J Cancer. 1982 Mar 15;29(3):239-47. doi: 10.1002/ijc.2910290303.
A case-control study of non-Hodgkin's lymphoma (NHL) and its subtypes among males was conducted using computerized mortality listings from the State of Wisconsin for the years 1968-1974. Age, year of death, race, county of usual residence, marital status, and usual occupation were abstracted for the 774 records of male deaths due to NHL and a matched series of deaths due to other causes. The frequency of farming occupation among NHL cases was compared to the frequency among controls, and odds ratios (OR) were calculated. Farming was more common among cases than among controls (OR = 1.22). The association of NHL with farming occupation was greater among decedents under 65 years of age (OR = 1.7) than among those who were older. The younger decedents were at higher risk of reticulum-cell sarcoma (OR = 2.7) than of other cell types. The strength of the association increased over the 9-year study period. County levels of selected agricultural characteristics were used as surrogate measures of farming exposures in residence counties of farmers and were summarized by factor analysis. Major findings were of elevated risk among younger farmers for reticulum-cell sarcoma in counties high in summary measures of general agricultural activity (OR = 3.2), of small grain acreage and acres treated with insecticides (OR = 6.6), and of wheat acreage (OR = 4.4). Given the limitations of the data, further investigation of non-Hodgkin's lymphoma in farmers is warranted.
利用威斯康星州1968 - 1974年的计算机化死亡记录，对男性非霍奇金淋巴瘤（NHL）及其亚型进行了一项病例对照研究。从774例因NHL死亡的男性记录以及一系列匹配的其他原因导致的死亡记录中提取了年龄、死亡年份、种族、常住县、婚姻状况和通常职业等信息。将NHL病例中从事农业职业的频率与对照组的频率进行比较，并计算优势比（OR）。从事农业职业在病例中比在对照组中更常见（OR = 1.22）。NHL与农业职业的关联在65岁以下的死者中（OR = 1.7）比在年龄较大者中更强。较年轻的死者患网状细胞肉瘤的风险（OR = 2.7）高于其他细胞类型。在9年的研究期间，这种关联的强度有所增加。选定农业特征的县水平被用作农民居住县农业暴露的替代指标，并通过因子分析进行总结。主要发现是，在一般农业活动综合指标较高（OR = 3.2）、小谷物种植面积和使用杀虫剂处理面积较大（OR = 6.6）以及小麦种植面积较大（OR = 4.4）的县，较年轻农民患网状细胞肉瘤的风险升高。鉴于数据的局限性，有必要对农民中的非霍奇金淋巴瘤进行进一步调查。
