Adler J H
Isr J Med Sci. 1982 Jan;18(1):187-91.
Sand rats develop a hyperglycemic-hyperinsulinemic syndrome when in positive energy balance. Sixteen animals fed a standard laboratory chow ad lib were studied for eight months. At five months, some became hyperglycemic and hyperinsulinemic, others were normoglycemic with or without hyperinsulinemia. As a rule, the hyperglycemic sand rats in the fed state when fasted overnight also had high glucose levels, elevated plasma insulin and reduced glucose tolerance. At eight months, some had not survived, the condition of others deteriorated, and some remained stable, as judged by blood glucose and plasma insulin levels or glucose tolerance. Thus, the pattern of response was highly variable. Sand rats that were maintained in negative energy balance by food deprivation for six days developed hyperglycemia and remained hyperinsulinemic. A hypothesis reconciling the apparent paradox of a similar syndrome appearing under opposite conditions of nutrition is presented in the form of an equation that can account for different patterns of circulating glucose-insulin relationships associated with varying degrees of insulin resistance.
沙地大鼠在能量正平衡时会出现高血糖-高胰岛素血症综合征。对16只随意进食标准实验室饲料的动物进行了为期8个月的研究。在5个月时，一些动物出现高血糖和高胰岛素血症，另一些动物血糖正常，伴有或不伴有高胰岛素血症。通常，禁食过夜的进食状态下的高血糖沙地大鼠血糖水平也较高，血浆胰岛素升高，葡萄糖耐量降低。在8个月时，一些动物没有存活下来，另一些动物的状况恶化，还有一些动物保持稳定，这是根据血糖、血浆胰岛素水平或葡萄糖耐量判断的。因此，反应模式高度可变。通过禁食6天保持能量负平衡的沙地大鼠出现高血糖并持续高胰岛素血症。以一个方程的形式提出了一个假说，该假说调和了在相反营养条件下出现类似综合征这一明显矛盾现象，该方程可以解释与不同程度胰岛素抵抗相关的循环葡萄糖-胰岛素关系的不同模式。
