Barnett M, Collier G R, Zimmet P, O'Dea K
School of Nutrition and Public Health, Deakin University, Geelong, Victoria, Australia.
Int J Obes Relat Metab Disord. 1994 Dec;18(12):789-94.
The aim of this paper was to determine whether restricting energy intake would reduce the elevated levels of glucose, insulin, cholesterol and triglyceride in diabetic Psammomys obesus (sand rat). Between 11 and 12 weeks of age Psammomys obesus were divided into three groups based on blood glucose and plasma insulin levels in the fed ad libitum state; group 1 was normoglycemic (4.4 +/- 0.3 mM) and normoinsulinemic (0.46 +/- 0.04 ng/ml), group 2 was normoglycemic (5.0 +/- 0.3 mM) and hyperinsulinemic (3.58 +/- 0.62 ng/ml) and group 3 was hyperglycemic (11.2 +/- 1.2 mM) and hyperinsulinemic (6.23 +/- 0.73 ng/ml). Energy intake was restricted to 67% of normal for 2 weeks before ad libitum feeding was resumed for a further 2 weeks. Animals in group 3 developed the most abnormalities when compared to group 1 including increased levels of food intake (16.3 +/- 0.5 vs 14.2 +/- 0.5 g/day, P < 0.05), body weight (192 +/- 5 vs 162 +/- 4 g, P < 0.05), triglycerides (1.5 +/- 0.2 vs 0.96 +/- 0.08 mM, P < 0.05), and cholesterol (2.8 +/- 0.2 vs 2.1 +/- 0.1 mM, P < 0.05). In group 3, food restriction was effective in reducing glucose levels (but not insulin) both during and following the restriction period respectively (11.2 +/- 1.2 vs 4.6 +/- 0.5, and 5.9 +/- 1.3, mM, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
本文的目的是确定限制能量摄入是否会降低糖尿病肥胖沙鼠（沙鼠）体内升高的葡萄糖、胰岛素、胆固醇和甘油三酯水平。在11至12周龄时，根据随意进食状态下的血糖和血浆胰岛素水平，将肥胖沙鼠分为三组；第1组血糖正常（4.4±0.3 mM）且胰岛素正常（0.46±0.04 ng/ml），第2组血糖正常（5.0±0.3 mM）且胰岛素水平高（3.58±0.62 ng/ml），第3组血糖高（11.2±1.2 mM）且胰岛素水平高（6.23±0.73 ng/ml）。在恢复随意进食另外2周之前，将能量摄入限制在正常水平的67%，持续2周。与第1组相比，第3组动物出现的异常情况最多，包括食物摄入量增加（16.3±0.5 vs 14.2±0.5 g/天，P<0.05）、体重增加（192±5 vs 162±4 g，P<0.05）、甘油三酯升高（1.5±0.2 vs 0.96±0.08 mM，P<0.05）和胆固醇升高（2.8±0.2 vs 2.1±0.1 mM，P<0.05）。在第3组中，食物限制在限制期内和限制期后均有效地降低了葡萄糖水平（但未降低胰岛素水平）（分别为11.2±1.2 vs 4.6±0.5，以及5.9±1.3 mM，P<0.05）。（摘要截断于250字）
