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人体内的大豆蛋白抗体:它们在乳糜泻中的出现及其可能的相关性。

Soya protein antibodies in man: their occurrence and possible relevance in coeliac disease.

作者信息

Haeney M R, Goodwin B J, Barratt M E, Mike N, Asquith P

出版信息

J Clin Pathol. 1982 Mar;35(3):319-22. doi: 10.1136/jcp.35.3.319.

DOI:10.1136/jcp.35.3.319
PMID:7040491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC497538/
Abstract

Circulating antibodies to soya-derived protein antigens have been measured in patients with duodenitis, Crohn's disease, ulcerative colitis and coeliac disease. Significantly raised antibody titres were found frequently in the coeliac group, particularly those patients showing a suboptimal response to a gluten-free diet, but rarely in subjects with other gastrointestinal diseases. Antisoya activity was not necessarily accompanied by antibodies to other common dietary antigens. We suggest that some coeliacs may have an associated dietary soya sensitivity which could adversely influence their response to gluten withdrawal.

摘要

已对患有十二指肠炎症、克罗恩病、溃疡性结肠炎和乳糜泻的患者检测了针对大豆衍生蛋白抗原的循环抗体。在乳糜泻组中经常发现抗体滴度显著升高,尤其是那些对无麸质饮食反应欠佳的患者,但在患有其他胃肠道疾病的受试者中很少见。抗大豆活性不一定伴有针对其他常见饮食抗原的抗体。我们认为,一些乳糜泻患者可能伴有饮食大豆敏感性,这可能会对他们停用麸质的反应产生不利影响。

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1
Soya protein antibodies in man: their occurrence and possible relevance in coeliac disease.人体内的大豆蛋白抗体:它们在乳糜泻中的出现及其可能的相关性。
J Clin Pathol. 1982 Mar;35(3):319-22. doi: 10.1136/jcp.35.3.319.
2
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引用本文的文献

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Integrated defense system overlaps as a disease model: with examples for multiple chemical sensitivity.作为一种疾病模型的综合防御系统重叠:以多重化学敏感性为例。
Environ Health Perspect. 1998 Feb;106 Suppl 1(Suppl 1):85-109. doi: 10.1289/ehp.98106s185.

本文引用的文献

1
SEROLOGIC REACTIONS TO GLUTEN AND COW'S MILK PROTEINS IN GASTROINTESTINAL DISEASE.胃肠道疾病中对麸质和牛奶蛋白的血清学反应
Gastroenterology. 1964 Feb;46:99-108.
2
Gluten-induced enteropathy: the effect of partially digested gluten.麸质诱导的肠病:部分消化的麸质的作用
Lancet. 1959 Sep 5;2(7097):252-5. doi: 10.1016/s0140-6736(59)92051-3.
3
Circulating antibodies to milk proteins in ulcerative colitis.溃疡性结肠炎患者体内针对乳蛋白的循环抗体。
Br Med J. 1961 Oct 7;2(5257):924-9. doi: 10.1136/bmj.2.5257.924.
4
Soy protein--another cause of the flat intestinal lesion.大豆蛋白——肠道扁平病变的另一个成因。
Gastroenterology. 1972 Feb;62(2):227-34.
5
Coeliac disease. Introduction and definition.乳糜泻。引言与定义。
Clin Gastroenterol. 1974 Jan;3(1):3-10.
6
Diagnosis of allergy by an in-vitro test for allergen antibodies.通过过敏原抗体体外检测诊断过敏。
Lancet. 1967 Nov 25;2(7526):1105-7. doi: 10.1016/s0140-6736(67)90615-0.
7
Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.酶联免疫吸附测定法,即酶标法。3. 通过在包被抗原的试管中用酶标记抗免疫球蛋白来定量特异性抗体。
J Immunol. 1972 Jul;109(1):129-35.
8
Circulating antibodies to bovine albumin in ulcerative colitis and Crohn's disease. Characterization of the antibody response.溃疡性结肠炎和克罗恩病中针对牛白蛋白的循环抗体。抗体反应的特征
Gastroenterology. 1976 Jan;70(1):5-8.
9
Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases.伴有牛奶不耐受的吸收不良综合征。54例临床 findings及病程。 需注意,这里“findings”直接保留英文未翻译,因为它在医学语境中有特定含义,一般不进行生硬翻译,可理解为“表现、发现等”,整体译文可能需要根据更完整的文本进一步优化表述,但仅针对这部分要求是按此呈现。
Arch Dis Child. 1975 May;50(5):351-6. doi: 10.1136/adc.50.5.351.
10
Gastrointestinal allergy to soyabean protein in preruminant calves. Antibody production and digestive disturbances in calves fed heated soyabean flour.
Res Vet Sci. 1979 Nov;27(3):361-5.