Falchuk K R, Isselbacher K J
Gastroenterology. 1976 Jan;70(1):5-8.
The presence of antibodies against a dietary protein, bovine serum albumin (BSA), was investigated in the serum of normal subjects and patients with inflammatory bowel disease and celiac disease. Antibodies to BSA were demonstrated in 28 of 30 patients with ulcerative colities (93%), 30 of 35 with Crohn's disease (86%), 5 with untreated celiac disease and in 12 of 28 normal subjects (43%). In patients with inflammatory bowel disease, antibodies to BSA were present in greater amounts in those with severe and moderate disease than in those with mild disease. Moreover, in those patients with high titers of circulating antibody, the serum anti-BSA activity was always associated with IgG and sometimes with IgA. These findings suggest that an increased absorption of antigenic material and stimulation of antibody production may occur in association with intestinal mucosal damage, not only in ulcerative colitis and celiac disease, but also in Crohn's disease.
研究了正常受试者以及患有炎症性肠病和乳糜泻患者血清中针对饮食蛋白牛血清白蛋白（BSA）的抗体情况。在30例溃疡性结肠炎患者中有28例（93%）检测到抗BSA抗体，35例克罗恩病患者中有30例（86%），5例未经治疗的乳糜泻患者以及28例正常受试者中有12例（43%）检测到该抗体。在炎症性肠病患者中，病情严重和中度的患者体内抗BSA抗体的含量高于轻度患者。此外，在那些循环抗体滴度高的患者中，血清抗BSA活性总是与IgG相关，有时也与IgA相关。这些发现表明，不仅在溃疡性结肠炎和乳糜泻中，而且在克罗恩病中，与肠黏膜损伤相关的抗原物质吸收增加和抗体产生刺激可能会发生。
