Singhvi S M, McKinstry D N, Shaw J M, Willard D A, Migdalof B H
J Clin Pharmacol. 1982 Feb-Mar;22(2-3):135-40. doi: 10.1002/j.1552-4604.1982.tb02661.x.
14C-Captopril was administered as 100-mg tablets to 12 subjects in a two-way crossover study in which subjects were either fasted or were given a standard meal immediately prior to dosing. Based on blood level and urinary excretion data, both the absorption of total radioactivity and the bioavailability of captopril were decreased approximately 35 to 40 per cent after a meal. Whether this moderate decrease in the absorption and the bioavailability of captopril caused by food is of clinical significance has not yet been determined.
在一项双向交叉研究中，12名受试者服用了100毫克片剂的14C-卡托普利，受试者在给药前要么禁食，要么立即给予标准餐。根据血药浓度和尿排泄数据，进食后总放射性的吸收和卡托普利的生物利用度均降低了约35%至40%。食物引起的卡托普利吸收和生物利用度的这种适度降低是否具有临床意义尚未确定。
