噬菌体T4中DNA复制叉起始的两种替代机制：RNA聚合酶引发和重组引发。
Two alternative mechanisms for initiation of DNA replication forks in bacteriophage T4: priming by RNA polymerase and by recombination.
作者信息
Luder A, Mosig G
出版信息
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1101-5. doi: 10.1073/pnas.79.4.1101.
Abstract
We show that bacteriophage T4 has two alternative mechanisms to initiate DNA replication; one dependent on Escherichia coli RNA polymerase (RNA nucleotidyltransferase, EC 2.7.7.6), and one dependent on general recombination. Continued DNA synthesis under recombination-defective conditions was sensitive to rifampin, an inhibitor of RNA polymerase. On the other hand, DNA synthesis accelerated in spite of the present of rifampin if recombination occurred.
摘要
我们发现噬菌体T4有两种启动DNA复制的替代机制；一种依赖于大肠杆菌RNA聚合酶（RNA核苷酸转移酶，EC 2.7.7.6），另一种依赖于一般重组。在重组缺陷条件下持续的DNA合成对RNA聚合酶抑制剂利福平敏感。另一方面，如果发生重组，尽管存在利福平，DNA合成仍会加速。
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