Syeda Aisha H, Hawkins Michelle, McGlynn Peter
Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom.
Cold Spring Harb Perspect Biol. 2014 Oct 23;6(11):a016550. doi: 10.1101/cshperspect.a016550.
The links between recombination and replication have been appreciated for decades and it is now generally accepted that these two fundamental aspects of DNA metabolism are inseparable: Homologous recombination is essential for completion of DNA replication and vice versa. This review focuses on the roles that recombination enzymes play in underpinning genome duplication, aiding replication fork movement in the face of the many replisome barriers that challenge genome stability. These links have many conserved features across all domains of life, reflecting the conserved nature of the substrate for these reactions, DNA.
几十年来,人们已经认识到重组与复制之间的联系,现在普遍认为DNA代谢的这两个基本方面是不可分割的:同源重组对于DNA复制的完成至关重要,反之亦然。本综述重点关注重组酶在支持基因组复制中所起的作用,在面对许多挑战基因组稳定性的复制体障碍时帮助复制叉移动。这些联系在生命的所有领域都有许多保守特征,反映了这些反应底物DNA的保守性质。