Thommen-Scott K
Agents Actions. 1981 Dec;11(6-7):770-3. doi: 10.1007/BF01978803.
Cyclosporin A has been shown to possess antimalarial activity in mice infected with Plasmodium berghei NK 65 or Plasmodium chabaudi. Significant antimalarial effects were obtained with five daily oral doses of 25 mg/kg. Cyclosporin A treatment started concurrently with the inoculation of parasites was less effective than treatment started when parasitaemia was already established. Evidence so far suggests that the antimalarial action results from a direct toxic effect on the parasite. Combined treatment with Cyclosporin A and Pyrimethamine indicated that the two compounds may act synergistically.
环孢素A已被证明对感染伯氏疟原虫NK 65或查巴迪疟原虫的小鼠具有抗疟活性。每日口服5次，每次25 mg/kg，可获得显著的抗疟效果。在接种寄生虫的同时开始环孢素A治疗，其效果不如在已经出现寄生虫血症时开始治疗。目前的证据表明，抗疟作用是由对寄生虫的直接毒性作用引起的。环孢素A与乙胺嘧啶联合治疗表明，这两种化合物可能具有协同作用。
