Black R H, Ray A P
Ann Trop Med Parasitol. 1977 Jun;71(2):131-9. doi: 10.1080/00034983.1977.11687171.
An accurate system with stringent criteria has been established to test antimalarial drugs and drug combinations against Plasmodium berghei in mice. Minimum effective doses for a number of antimalarial drugs have been determined when used in this system. Considerable potentiation of the activity of pyrimethamine and to a somewhat less extent of proguanil by dapsone has been demonstrated. The need to extend studies of these combinations to the parasites of human malaria is discussed in terms of establishing a safe chemoprophylactic regime in the presence of drug-resistant strains of parasites.
已经建立了一个具有严格标准的精确系统，用于在小鼠中测试抗疟药物和药物组合对伯氏疟原虫的作用。在该系统中使用时，已经确定了多种抗疟药物的最小有效剂量。已经证明，氨苯砜可显著增强乙胺嘧啶的活性，对氯胍的增强作用稍弱。从在存在抗药寄生虫菌株的情况下建立安全的化学预防方案的角度，讨论了将这些组合的研究扩展到人类疟疾寄生虫的必要性。
