Chaparas S D
Crit Rev Microbiol. 1982;9(2):139-97. doi: 10.3109/10408418209104488.
Mycobacteria are endowed with substances that profoundly affect the immune system. Leprosy and tuberculosis exemplify broad spectra of useful and detrimental immune responses of mycobacterial infections that range from intense potentiation to severe specific adn nonspecific suppression of humoral and cellular immune elements. The cellular hypersensitivity induced by mycobacteria serves as a classical model for the analysis of specific and nonspecific immune mechanisms. Mycobacterial disease are prevalent worldwide and rank among the most important bacterial diseases. The kaleidoscope of immunologic events induced by injected mycobacteria and during infections will be reviewed from the standpoint of pathogenesis, pathology, in vitro and in vivo effects on cellular and humoral arms of the immune response, diagnosis, classification, potentiation and suppression.
分枝杆菌具有能深刻影响免疫系统的物质。麻风病和结核病是分枝杆菌感染中有益和有害免疫反应广泛谱的典型例子，这些反应范围从强烈增强到对体液和细胞免疫成分的严重特异性和非特异性抑制。分枝杆菌诱导的细胞超敏反应是分析特异性和非特异性免疫机制的经典模型。分枝杆菌病在全球流行，是最重要的细菌性疾病之一。将从发病机制、病理学、对免疫反应的细胞和体液分支的体外和体内影响、诊断、分类、增强和抑制等角度，对注射分枝杆菌后以及感染期间引发的一系列免疫事件进行综述。
