Azar H A, Espinoza C G, Richman A V, Saba S R, Wang T
Hum Pathol. 1982 Apr;13(4):323-33. doi: 10.1016/s0046-8177(82)80222-0.
One of the most difficult areas of surgical pathology is the classification of "undifferentiated" or "anaplastic" large cell malignant tumors. The differential diagnosis of these tumors includes poorly differentiated carcinomas, large cell malignant lymphomas, and amelanotic malignant melanomas. In this study of 56 such cases, the application of electron microscopy and, in selected instances, of indirect immunofluorescence and immunoperoxidase staining methods have helped us reach a precise histopathologic diagnosis in the majority of neoplasms that were considered to be "undifferentiated" by light microscopy.
外科病理学中最具挑战性的领域之一是“未分化”或“间变性”大细胞恶性肿瘤的分类。这些肿瘤的鉴别诊断包括低分化癌、大细胞恶性淋巴瘤和无黑色素性恶性黑色素瘤。在这项对56例此类病例的研究中，电子显微镜的应用，以及在特定情况下间接免疫荧光和免疫过氧化物酶染色方法的应用，帮助我们对大多数在光学显微镜下被认为是“未分化”的肿瘤做出了精确的组织病理学诊断。
