Gillespie J J
Diagn Histopathol. 1982 Jan-Mar;5(1):33-51.
Large cell undifferentiated neoplasia' provides a generic designation for a heterogeneous group of neoplasms which by histological study, are devoid of discriminate architecture and appear under the light microscope as patternless sheets of large cytoplasmic cells. The interpretation of such a tumour will routinely present significant problems in differential diagnosis. By conventional light microscopy the neoplasm may subjectively be judged to represent a certain form of carcinoma or large cell lymphoma, but often identification is relegated to a label of "consistent with', or "undifferentiated malignant neoplasm'. Such interpretations are not acceptable and preclude rational management decisions. This paper has analysed tumour cell ultrastructure derived from a spectrum of clinicopathological situations involving the diagnostic problem of the large cell undifferentiated neoplasm. The fine structural morphologies of these enigmatic tumours are often sufficiently specific to allow resolution of the differential diagnosis and assignment of cell type. Diagnostic electron microscopy, in coordination with histopathology and clinical information, will often play a significant role in solving complex problems involving the differential diagnosis of large cell undifferentiated neoplasms.
“大细胞未分化肿瘤”是一组异质性肿瘤的通用名称，通过组织学研究，这些肿瘤缺乏明显的结构，在光学显微镜下表现为无模式的大细胞质细胞片。对这类肿瘤的解读在鉴别诊断中通常会出现重大问题。通过传统光学显微镜，肿瘤可能会主观地被判断为某种形式的癌或大细胞淋巴瘤，但通常只能给出“符合”或“未分化恶性肿瘤”这样的诊断。这种解读是不可接受的，并且无法做出合理的治疗决策。本文分析了一系列临床病理情况中产生的肿瘤细胞超微结构，这些情况涉及大细胞未分化肿瘤的诊断问题。这些神秘肿瘤的精细结构形态通常具有足够的特异性，能够解决鉴别诊断问题并确定细胞类型。诊断性电子显微镜与组织病理学和临床信息相结合，在解决涉及大细胞未分化肿瘤鉴别诊断的复杂问题时往往会发挥重要作用。
